Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial
Identifieur interne : 002631 ( Main/Exploration ); précédent : 002630; suivant : 002632Short‐term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo‐controlled trial
Auteurs : Maria Stamelou [Allemagne] ; Alexander Reuss [Allemagne] ; Ulrich Pilatus [Allemagne] ; Jörg Magerkurth [Allemagne] ; Petra Niklowitz [Allemagne] ; Karla M. Eggert [Allemagne] ; Andrea Krisp [Allemagne] ; Thomas Menke [Allemagne] ; Carmen Schade-Brittinger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Günter U. Höglinger [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Basal Ganglia (drug effects), Basal Ganglia (metabolism), Clinical trial, Double-Blind Method, Energy metabolism, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, NMR spectrometry, Nervous system diseases, Neuroprotective Agents (pharmacology), Neuroprotective Agents (therapeutic use), Placebo, Short term, Supranuclear Palsy, Progressive (drug therapy), Ubiquinone (analogs & derivatives), Ubiquinone (pharmacology), Ubiquinone (therapeutic use), coenzyme Q10, energy metabolism, magnetic resonance spectroscopy, progressive supranuclear palsy, randomized controlled clinical trial (CONSORT statement).
- MESH :
- chemical , analogs & derivatives : Ubiquinone.
- chemical , pharmacology : Neuroprotective Agents, Ubiquinone.
- drug effects : Basal Ganglia.
- drug therapy : Supranuclear Palsy, Progressive.
- metabolism : Basal Ganglia.
- chemical , therapeutic use : Neuroprotective Agents, Ubiquinone.
- Adult, Aged, Double-Blind Method, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged.
Abstract
Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22023
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15">2008-05-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="942">942</biblScope><biblScope unit="page" to="949">949</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FE411EB6419C546541B9B6910C430C9F66C6F4D4</idno><idno type="DOI">10.1002/mds.22023</idno><idno type="ArticleID">MDS22023</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Basal Ganglia (drug effects)</term><term>Basal Ganglia (metabolism)</term><term>Clinical trial</term><term>Double-Blind Method</term><term>Energy metabolism</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Middle Aged</term><term>NMR spectrometry</term><term>Nervous system diseases</term><term>Neuroprotective Agents (pharmacology)</term><term>Neuroprotective Agents (therapeutic use)</term><term>Placebo</term><term>Short term</term><term>Supranuclear Palsy, Progressive (drug therapy)</term><term>Ubiquinone (analogs & derivatives)</term><term>Ubiquinone (pharmacology)</term><term>Ubiquinone (therapeutic use)</term><term>coenzyme Q10</term><term>energy metabolism</term><term>magnetic resonance spectroscopy</term><term>progressive supranuclear palsy</term><term>randomized controlled clinical trial (CONSORT statement)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ubiquinone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neuroprotective Agents</term><term>Ubiquinone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Neuroprotective Agents</term><term>Ubiquinone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Court terme</term><term>Essai clinique</term><term>Métabolisme énergétique</term><term>Pathologie du système nerveux</term><term>Placebo</term><term>Spectrométrie RMN</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q10 (CoQ10) is a physiological cofactor of complex I. Therefore, we evaluated the short‐term effects of CoQ10 in PSP. We performed a double‐blind, randomized, placebo‐controlled, phase II trial, including 21 clinically probable PSP patients (stage ≤ III) to receive a liquid nanodispersion of CoQ10 (5 mg/kg/day) or matching placebo. Over a 6‐week period, we determined the change in CoQ10 serum concentration, cerebral energy metabolites (by 31P‐ and 1H‐magnetic resonance spectroscopy), motor and neuropsychological dysfunction (PSP rating scale, UPDRS III, Hoehn and Yahr stage, Frontal Assessment Battery, Mini Mental Status Examination, Montgomery Åsberg Depression Scale). CoQ10 was safe and well tolerated. In patients receiving CoQ10 compared to placebo, the concentration of low‐energy phosphates (adenosine‐diphosphate, unphosphorylated creatine) decreased. Consequently, the ratio of high‐energy phosphates to low‐energy phosphates (adenosine‐triphosphate to adenosine‐diphosphate, phospho‐creatine to unphosphorylated creatine) increased. These changes were significant in the occipital lobe and showed a consistent trend in the basal ganglia. Clinically, the PSP rating scale and the Frontal Assessment Battery improved slightly, but significantly, upon CoQ10 treatment compared to placebo. Since CoQ10 appears to improve cerebral energy metabolism in PSP, long‐term treatment might have a disease‐modifying, neuroprotective effect. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name></region><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><name sortKey="Krisp, Andrea" sort="Krisp, Andrea" uniqKey="Krisp A" first="Andrea" last="Krisp">Andrea Krisp</name><name sortKey="Magerkurth, Jorg" sort="Magerkurth, Jorg" uniqKey="Magerkurth J" first="Jörg" last="Magerkurth">Jörg Magerkurth</name><name sortKey="Menke, Thomas" sort="Menke, Thomas" uniqKey="Menke T" first="Thomas" last="Menke">Thomas Menke</name><name sortKey="Niklowitz, Petra" sort="Niklowitz, Petra" uniqKey="Niklowitz P" first="Petra" last="Niklowitz">Petra Niklowitz</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Pilatus, Ulrich" sort="Pilatus, Ulrich" uniqKey="Pilatus U" first="Ulrich" last="Pilatus">Ulrich Pilatus</name><name sortKey="Reuss, Alexander" sort="Reuss, Alexander" uniqKey="Reuss A" first="Alexander" last="Reuss">Alexander Reuss</name><name sortKey="Schade Rittinger, Carmen" sort="Schade Rittinger, Carmen" uniqKey="Schade Rittinger C" first="Carmen" last="Schade-Brittinger">Carmen Schade-Brittinger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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